Gene expression activity is heterogeneous in a population of isogenic cells. Identifying the molecular basis of this variability will improve our understanding of phenomena like tumor resistance to drugs, virus infection, or cell fate choice. The complexity of the molecular steps and machines involved in transcription and translation could introduce sources of randomness at many levels, but a common constraint to most of these processes is its energy dependence. In eukaryotic cells, most of this energy is provided by mitochondria. A (...) clonal population of cells may show a large variability in the number and functionality of mitochondria. Here, we discuss how differences in the mitochondrial content of each cell contribute to heterogeneity in gene products. Changes in the amount of mitochondria can also entail drastic alterations of a cell's gene expression program, which ultimately leads to phenotypic diversity. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Journal of Aesthetic Education 40.1 (2006) 35-53 [Access article in PDF] "Truth Is What Works": Francisco J. Varela on Cognitive Science, Buddhism, the Inseparability of Subject and Object, and the Exaggerations of Constructivism—A Conversation Francisco J. Varela Bernhard Poerksen Institut für Journalistik und Kommunikationswissenschaft Universität Hamburg Francisco J. Varela (1946-2001) studied biology in Santiago de Chile, obtained his doctorate 1970 at Harvard University with a (...) dissertation on the insect eye, and worked there for some time in the laboratory of Torsten Wiesel, the later Nobel Laureate for medicine. From his scientific beginnings as a researcher in biology, he not only studied and practiced biology but, resisting the dominating mainstream, pursued a research program that ignored and broke down traditional disciplinary boundaries. This research program is best characterized as experimental epistemology, a concept introduced by the neuropsychiatrist and cybernetician Warren S. McCulloch. Francisco J. Varela's great aspiration was to examine and answer the philosophical ur-question of cognition with scientific precision and with the help of the best possible theoretical framework. [End Page 35]Having obtained his doctorate, he went back to Chile to work as a professor of biology together with Humberto R. Maturana. He contributed to the writing of the theory of autopoiesis, which was to cause a furor in the world of science as a universally applicable explanatory model. After the overthrow of Allende and the installation of the dictatorship by the putsch general Pinochet, Francisco J. Varela first escaped to Costa Rica, then became a professor at the American University of Colorado and University of New York, and finally returned in 1980 to the University of Chile in Santiago for five years. Temporary positions as guest professor for neurobiology, philosophy, and cognitive science in Germany, Switzerland, and France led him to Paris in the end, where he worked as research director of the Centre National de Recherche Scientifique until his death on May 28, 2001.In his research work embracing cognitive science, evolutionary theory, and immunology, Francisco J. Varela, constantly inspired by his fundamental interest in the key questions of epistemology, gave the epistemological debate a new orientation. In his thinking he refuses to accept the strict separation of subject and object, of knower and known, which as a rule unites realists and constructivists alike. Francisco J. Varela rejects the fundamental dualism dividing mind and world, which had shaped Western philosophy from its earliest beginnings. He does not subscribe to the idea that human individuals can invent their own realities—blindly and arbitrarily, and without experiencing any resistance from the external world and all other things given. He equally distances himself, however, from the diametrically opposite position that overstates the eigenpower of the world of objects. The external world and all other things given cannot determine what happens in an organism. Varela's claim is that individual and world create each other. The Computational Model of the Mind Poerksen: The ancient key questions of philosophy are at the center of modern cognitive science. What is the essence of the mind? Do our conceptions represent a given world, which is independent from our minds? What is the formative power of external objects over our perceptions? How does cognition function? The search for an adequate answer and an improved understanding of the human mind has led many cognitive scientists to entertain the assumption that the brain is actually a kind of computer. Memory is taken to be a store. Thinking and perceiving are understood as data processing in the sense that an independent external world is computationally transformed into symbols and represented in the organism in this manner. You are very critical of this view. Why?Varela: If the brain is considered as a kind of computer, then cognitive research is limited to discovering certain self-sufficient shapes—the symbols—together with the rules [End Page 36] governing them—the programs. But this search for symbols and programs will never be profitable because it... (shrink)

The Embodied Mind provides a unique, sophisticated treatment of the spontaneous and reflective dimension of human experience.

Searches for the sources and means for a disciplined practical approach to exploring human experience.

How can science be brought to connect with experience? This book addresses two of the most challenging problems facing contemporary neurobiology and cognitive science. Firstly, understanding how we unconsciously execute habitual actions as a result of neurological and cognitive processes that are not formal actions of conscious judgment but part of a habitual nexus of systematic self-organization. Secondly, attempting to create an ethics adequate to our present awareness that there is no such thing as a transcendental self, a stable subject (...) or soul. The author combines researches in cognitive science and phenomenology with two representatives of what he calls the 'wisdom traditions': Confucianism and Buddhist epistemology. (shrink)

The question whether ethical behavior is biologically determined may refer either to the capacity for ethics (i.e., the proclivity to judge human actions as either right or wrong), or to the moral norms accepted by human beings for guiding their actions. I herein propose: (1) that the capacity for ethics is a necessary attribute of human nature; and (2) that moral norms are products of cultural evolution, not of biological evolution. Humans exhibit ethical behavior by nature because their biological makeup (...) determines the presence of three necessary conditions for ethical behavior: (i) the ability to anticipate the consequences of one’s own actions; (ii) the ability to make value judgments; and (iii) the ability to choose between alternative courses of action. Ethical behavior came about in evolution not because it is adaptive in itself, but as a necessary consequence of man’s eminent intellectual abilities, which are an attribute directly promoted by natural selection. That is, morally evolved as an exaptation, not as an adaptation. Since Darwin’s time there have been evolutionists proposing that the norms of morality are derived from biological evolution. Sociobiologists represent the most recent and most subtle version of that proposal. The sociobiologists' argument is that human ethical norms are sociocultural correlates of behaviors fostered by biological evolution. I argue that such proposals are misguided and do not escape the naturalistic fallacy. The isomorphism between the behaviors promoted by natural selection and those sanctioned by moral norms exist only with respect to the consequences of the behaviors; the underlying causations are completely disparate. (shrink)

The present paper has a negative aim and a positive aim, both limited in the present context to a sketch or outline. The negative aim, today less controversial, is to show that Aristotle’s theory of final causality has little or nothing to do with the teleology rejected by modern science and that, therefore, far from having been rendered obsolete, it has yet to be fully understood. This aim will be met through the identification and brief discussion of some key points (...) on which Aristotle’s theory differs from teleology as still commonly understood. The positive aim is more controversial as it proposes that we take an ontology of life as the proper context for understanding the significance and nature of final causation in Aristotle. The argument for final causation, in other words, is that, without it, we would lose the phenomenon of life and, indeed, of nature altogether, reducing nature to the inanimate and mechanical. (shrink)

The present paper uses the theme of dialectic and dialogue to begin unraveling the similarities and differences between the hermeneutics of Paul Ricoeur and H.G. Gadamer. Ricoeur is shown to distance himself from Heidegger by insisting on a dimension of explanation and distanciation (which he sometimes identifies with Plato's `descending dialectic') that cannot be reduced to, or absorbed by, understanding and appropriation. This same move, however, leads him to reject Platonic dialogue, with the attendant prioritizing of oral conversation over the (...) written text, as a model for hermeneutics. Ricoeur therefore sees in Gadamer's recourse to such a model a regression to the problematic position of Heidegger. Yet the conception of philosophy as dialectical and dialogical which Gadamer finds in Plato is capable of responding to Ricoeur's objections. Where the fundamental difference between the hermeneutics of Ricoeur and Gadamer emerges is in the question of whether experience is fundamentally dialectical and whether language is inherently dialogical. (shrink)

The ultimate source of explanation in biology is the principle of natural selection. Natural selection means differential reproduction of genes and gene combinations. It is a mechanistic process which accounts for the existence in living organisms of end-directed structures and processes. It is argued that teleological explanations in biology are not only acceptable but indeed indispensable. There are at least three categories of biological phenomena where teleological explanations are appropriate.

The purpose of this paper is to show how interdisciplinary studies between the fields of law and literature can contribute to the debate on legal interpretation, and to the role of what legal operators actually do when deciding constitutional issues. First, we will review one of the possible meeting points between law and literature - i. e. law as literature - and we will examine Roland Barthes’ semiological proposal, specifically his theory about “The Death of the Author”; from there on, (...) we will show how the ideas and concepts he coined constitute one of the tools that best describe the mechanics of the current constitutional interpretation in some legal systems. This will lead to what we will call “The Death of the Lawmaker”. (shrink)

Knives, birds' wings, and mountain slopes are used for certain purposes: cutting, flying, and climbing. A bird's wings have in common with knives that they have been 'designed' for the purpose they serve, which purpose accounts for their existence, whereas mountain slopes have come about by geological processes independently of their uses for climbing. A bird's wings differ from a knife in that they have not been designed or produced by any conscious agent; rather, the wings, like the slopes, are (...) outcomes of natural processes without any intentional causation. Evolutionary biologists use teleological language and teleological explanations. I propose that this use is appropriate, because teleological explanations are hypotheses that can be subject to empirical testing. The distinctiveness of teleological hypotheses is that they account for the existence of a feature in terms of the function it serves; for example, wings have evolved and persist because flying is beneficial to birds by increasing their chances of surviving and reproducing. Features of organisms that are explained with teleological hypotheses include structures, such as wings; processes, such as development from egg to adult; and behaviours, such as nest building. A proximate explanation of these features is the function they serve; an ultimate explanation that they all share is their contribution to the reproductive fitness of the organisms. I distinguish several kinds of teleological explanations, such as natural and artificial, as well as bounded and unbounded, some of which but not others apply to biological explanations. (shrink)

El presente trabajo explora cómo la Inteligencia Artificial (IA) puede integrarse en los cuidados a personas dependientes y con discapacidad en España, resaltando su capacidad para promover la autonomía y la atención centrada en la persona. Inspirado en la Convención sobre los Derechos de las Personas conDiscapacidad de las Naciones Unidas, el documento propone un cambio del modelo institucionalizado de cuidado hacia uno comunitario y más integrado en el hogar, donde la tecnología, especialmente la IA, juegue un papel crucial. Se (...) discuten los beneficios y riesgos de la IA en los cuidados, como mejorar la calidad de vida y la eficiencia de los servicios, al tiempo que se plantea la necesidad de un análisis cuidadoso para evitar la discriminación y asegurar el respeto por los derechos humanos. Además, se detallan ejemplos de tecnologíasactuales, como robots de atención domiciliaria y sistemas de monitoreo remoto, mostrando la creciente integración de la IA en el ámbito de los cuidados. (shrink)

Francisco J. Gonzalez - Die Idee des Guten in Platons Politeia: Beobachtungen zu den mittleren Buchern - Journal of the History of Philosophy 43:3 Journal of the History of Philosophy 43.3 354-355 Thomas A. Szlezák. Die Idee des Guten in Platons Politeia: Beobachtungen zu den mittleren Büchern. Sankt Augustin: Academia, 2003. Pp. viii + 160. Cloth, € 24,50. The first part of this book consists of a series of lectures delivered at the University of Macerata in April 2000. These (...) lectures provide a detailed and illuminating analysis of the middle books of the Republic, with the focus naturally on the three great similes. Appended to these lectures are three previously published articles on the Cave Analogy, the Idea of the Good, and Rafael Ferber's supposedly "skeptical interpretation" of Plato . While some repetition is unavoidable in such a compilation, the different parts of the book for the most part complement and.. (shrink)

In the recently published 1924 course, Grundbegriffe der aristotelischen Philosophie, Martin Heidegger offers a detailed interpretation of Aristotle's definition of kinesis in the Physics. This interpretation identifies entelecheia with what is finished and present‐at‐an‐end and energeia with being‐at‐work toward this end. In arguing against this interpretation, the present paper attempts to show that Aristotle interpreted being from the perspective of praxis rather than poiesis and therefore did not identify it with static presence. The paper also challenges later variations of Heidegger's (...) interpretation, in particular his account of dunamis in the 1931 course on Metaphysics Theta, which insists that its mode of being is presence‐at‐hand. By arguing that this reading too is untenable, the paper concludes that Aristotle's metaphysics is not a metaphysics of presence and that his texts instead point toward a possibility of metaphysics ignored by the attempts of Heidegger and others to overcome it. (shrink)

During the 1920s Heidegger gave no less than twelve seminars and lecture courses devoted either exclusively or in large part to the reading of Aristotle's texts. Seven of these, especially the smaller seminars for advanced students, have not been published and apparently will never be included in the Gesamtausgabe. My focus here is on the very first of these. Billed as a reading of Aristotle's De Anima, much of it was devoted to Aristotle's Metaphysics. This decision not to separate Aristotle's (...) “psychology” from his “ontology” is a key move of the seminar that anticipates the project of Being and Time. This and many other ways in which Heidegger's early reading of De Anima anticipates the key moves of the later book constitute one of the reasons for its importance. Another is that the seminar allows us to see what gets suppressed in Heidegger's reading of Aristotle, most significantly, the phenomenon of life itself in favor of an eventual focus on the being of human life or Dasein. This early seminar thus enables us not only to better understand Heidegger's project, but also to raise some fundamental questions concerning it. (shrink)

This article attempts to elucidate the Deleuzian philosophy of the event between The Logic of Sense and A Thousand Plateaus, where it acquires clearly political nuances. With regard to The Logic of Sense, I show that (i) it takes up the definition of the event of Difference and Repetition, identifying it with that redistribution of pre-individual singularities or individuating differences at the level of the univocal being which defines the conditions of problems; (ii) the event is henceforth also the instance (...) that makes possible the “communication” of the heterogeneous series of bodies and propositions from which the production of sense in language follows; and (iii) the counter-effectuation should be understood in this book as an ethics of the event. With regard to A Thousand Plateaus, I emphasize (i) the “return” to The Logic of Sense that the concept of assemblage entails, (ii) the reformulation of the notion of event that takes place in the new theoretical framework, and (iii) that of the counter-effectuation, which must henceforth be understood as a politics of the event. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Form and Argument in Late Plato ed. by Christopher Gill and Mary Margaret McCabeFrancisco J. GonzalezChristopher Gill and Mary Margaret McCabe, editors. Form and Argument in Late Plato. Oxford: Oxford University Press, 1996. Pp. xi + 345. Cloth, $65.00.This collection has the commendable aim of challenging the view that in Plato’s “late” works the dialogue form is a mere formality adding little to the argumentative content, a view (...) still widespread among “analytic” scholars. The qualification is necessary because this view has already been seriously challenged by “nonanalytic” interpreters. It is therefore surprising that the editors chose contributors who almost all “share the analytic’ approach which is prominent in Anglo-American scholarship on Plato,” despite their admission that this approach has focused more on arguments than on the dialogue form (2, 299–300). Why seek to reinvent the wheel without the help of those who have already invented it? As a result, while the volume certainly makes an important contribution to our understanding of the form of this group of dialogues, it is much more successful in providing helpful and illuminating readings of their argumentative content: the detailed and rigorous analyses of McCabe, Malcolm Schofield (both on the Parmenides), and Gail Fine (on the Theaetetus) deserve special mention. The aim of the present review, which could not even begin to do justice to what the volume provides in the latter area, is therefore limited to documenting its mixed success in addressing some fundamental questions about form that have already occupied nonanalytic scholars (perhaps too exclusively):1) Does the main speaker speak for Plato?Given the great variety of main speakers in the “late” dialogues (Socrates, Parmenides, the Eleatic Stranger, Timaeus, the Athenian Stranger), each with a distinct personality and a distinct method, no attempt to understand the form of these dialogues should avoid this question. Gill raises it (293–95) and Schofield provides the most explicit response in denying that any interlocutor in a Platonic dialogue “can be assumed to be merely a spokesman for Plato’s own views” (51). More importantly, the essays by Dorothea Frede (on the Philebus) and Catherine Osborne (on the Timaeus), probably the most valuable in the volume, show what results can be achieved without this assumption. On the other hand, Michael Frede (on the Sophist) and Christopher Rowe (on the Politicus; see 158 and cf. 172 n.48) simply assume without argument that the Eleatic Stranger = Plato. All other contributors make the “spokesman” assumption, either implicitly or explicitly (see Christopher Bobonich’s reading of the Laws, 254–55).2) What is the significance of the dramatic context, especially dramatic chronology and characterization?As often noted, the Parmenides is set in Socrates’ youth and is in this sense the earliest [End Page 311] dialogue, while the series Theaetetus-Sophist-Politicus is set immediately before Socrates’ trial and condemnation. McCabe and Schofield are silent about the first fact. M. Frede briefly discusses the second (146–47), but adds little to what has already been said by others. As for the characterization of specific interlocutors, this volume overall has surprisingly little to offer. The essays of D. Frede and Osborne, however, are exemplary in this area.3) Why did Plato choose to write these works as dialogues rather than as treatises?Bobonich, D. Frede, and Osborne succeed in demonstrating the significance and even necessity of the dialogue form, an extraordinary achievement given the dialogues they discuss. Osborne in particular brilliantly shows how the dialogue form undercuts the common tendency to read the Timaeus as a treatise on natural science. Other contributors are less successful in answering this question central to the volume’s task. Schofield takes himself to be reading the Parmenides as a dialogue (51) because he, unlike Vlastos, interprets the Third Man Argument (second version) in the wider context of other arguments in the dialogue, including those of the second half. But “reading arguments in context” is demanded by any philosophical text and has nothing per se to do with the dialogue form. Fine reads the first part of the Theaetetus as the dialectical elaboration and refutation of an opponent’s view (109), but this could just as well be... (shrink)

I will, first, outline what we currently know about the last 4 million years of human evolutionary history, from bipedal but small‐brained Australopithecus to modern Homo sapiens, our species, through the prolific toolmaker Homo habilis and the continent wanderer Homo erectus. I shall then identify anatomical traits that distinguish us from other animals and point out our two kinds of heredity, the biological and the cultural.Biological inheritance is based on the transmission of genetic information, in humans very much the same (...) as in other sexually reproducing organisms. But cultural inheritance is distinctively human, based on transmission of information by a teaching and learning process that is in principle independent of biological parentage. Cultural inheritance makes possible the cumulative transmission of experience from generation to generation. Cultural heredity is a swifter and more effective (because it can be designed) mode of adaptation to the environment than the biological mode. The advent of cultural heredity ushered in cultural evolution, which transcends biological evolution.I will, finally, explore ethical behavior as a model case of a distinctive human trait, and seek to ascertain the causal connections between human ethics and human biology. My conclusions are that (1) moral reasoning—that is, the proclivity to make ethical judgments by evaluating actions as either good or evil—is rooted in our biological nature; it is a necessary outcome of our exalted intelligence, but (2) the moral codes that guide our decisions as to which actions are good and which ones are evil are products of culture, including social and religious traditions. This second conclusion contradicts those evolutionists and sociobiologists who claim that the morally good is simply that which is promoted by the process of biological evolution. (shrink)

Resumen Defiendo que lo novedoso de la concepción de Cicerón de los modelos basados en personajes del pasado consistió en conferirles habilidades que podían aplicarse a las disputas legales y políticas de Roma y, al mismo tiempo, mejorar el desempeño de los oradores jóvenes y aprendices mediante un modelo mixto de retórica. La destreza técnica y la prudencia práctica de estas autoridades para advertir aspectos cruciales en casos particulares y adaptarse a circunstancias adversas sirven como ejemplos para los oficios del (...) rétor y del abogado. Esas dos características, y no el amplio conocimiento o la fama que estos personajes alcanzaron, llevaron a Cicerón a reconocer a ciertos oradores y pensadores como fuentes de inspiración moral y formativa.I argue that Cicero's innovative understanding of the models based on characters from the past consisted in conferring them skills to be applied in the legal and political disputes of Rome and, at the same time, to improve the performance of young orators and apprentices with a mixed model of rhetoric. Both the technical ability and practical prudence of these authorities to see crucial aspects in particular cases and to adapt to adverse circumstances serve to the craft of rhetoricians and lawyers. These two features, and not the large knowledge or fame these figures acquired in life, took Cicero to recognise certain orators and thinkers as sources of moral and formative inspiration. (shrink)

_Dialectic and Dialogue_ seeks to define the method and the aims of Plato's dialectic in both the "inconclusive" dialogues and the dialogues that describe and practice a method of hypothesis. Departing from most treatments of Plato, Gonzalez argues that the philosophical knowledge at which dialectic aims is nonpropositional, practical, and reflexive. The result is a reassessment of how Plato understood the nature of philosophy.

This paper sets forth a familiar theme, that science essentially consists of two interdependent episodes, one imaginative, the other critical. Hypotheses and other imaginative conjectures are the initial stage of scientific inquiry because they provide the incentive to seek the truth and a clue as to where to find it. But scientific conjectures must be subject to critical examination and empirical testing. There is a dialogue between the two episodes; observations made to test a hypothesis are the inspiration for new (...) conjectures. Inductive generalizations may also inspire hypotheses, but cannot validate them. A hypothesis is empirically tested by ascertaining whether or not predictions about the world of experience deduced from the hypothesis agree with what is actually observed. This has been appropriately considered the 'criterion of demarcation' that distinguishes science from other knowledge. But scientific hypotheses must satisfy other tests as well, e.g., whether they have explanatory value and further understanding. I briefly explore such issues as verifiability and falsifiability, empirical content and truthfulness, contingency and certainty, fact and theory, error and fraud. Science like any human activity is subject to error and to the foibles and other failings of human beings. But severe attempts of empirical falsification and other trials yield knowledge that stands the test of time and provides a foothold for further knowledge. Moreover, scientists have developed social mechanisms, such as peer review and publication, to evaluate their work. Because the research of scientists depends on the validity of previous knowledge, it is of great consequence that they discern valid from invalid knowledge and thus scientists are inclined to transcend ideology, nationality, friendship, monetary interest and other prejudices when the mettle of scientific knowledge is at stake. I use historical examples to illustrate some relevant aspects of scientific practice: its success (Mendel), misrepresentation (Darwin), ideological abuse (Lysenko), arrogant violation of the requirement of testing (Koch), theory replacement (Priestly and Lavoisier, Newton and Einstein), and the indispensability of context (Oswald Avery and Alfred Wegener). (shrink)

La humanidad no solo ha evolucionado, sino que continúa evolucionando. ¿Hacia dónde va la evolución humana? La evolución biológica está dirigida por la selección natural, que no es un proceso benevolente que guíe a las especies hacia un éxito seguro. El resultado final puede ser la extinción. Los avances en genética, biología molecular y biomedicina han hecho posible manipular, rápida y efectivamente, la constitución genética de la humanidad. La terapia genética puede ser somática, o germinal. No hay intervenciones de terapia (...) germinal que estén siendo consideradas actualmente por científicos, médicos o compañías farmacéuticas. La clonación de humanos puede también referirse a clonación terapéutica o de individuos. Se han avanzado propuestas sugiriendo clonar individuos de gran capacidad intelectual o artística, o de virtud eminente. Tales propuestas utópicas son sumamente desafortunadas. No es posible clonar un individuo humano, aun si se clona su genoma. De genomas idénticos, desarrollados en contextos diferentes, familiares, sociales y culturales, pueden resultar individuos totalmente diferentes. Además, entran en juego consideraciones éticas, sociales y religiosas cuando se examina si una persona puede o debe ser clonada. (shrink)

This chapter contains sections titled: Introduction: The Design Argument The Design Argument in Antiquity Christian Authors Hume's Onslaught William Paley's Natural Theology The Bridgewater Treatises Intelligent Design: A Political Movement Eyes to See No “There” There Blood and Tears Gambling to Non‐existence Natural Selection Natural Selection and Design Postscript: Counterpoint Notes References.

The study examines the end or purpose of the acts of the virtue of religion within Thomas Aquinas' ethics of human action. What is the end of religious worship? Is it God, or is it the worshippers themselves? On the one hand, one would presume that God cannot be the end of religion because, from the perspective of Classical Theism (of which Aquinas is a main proponent), God cannot benefit from the activity of creatures. But on the other hand, if (...) the worshipper is the end of religious acts, would not worship be a self-centered or an egotistic act? The standard Thomistic account of the problem, first laid out by Cajetan and later adopted by countless followers, is that God is the finis cuius ("the aim toward which") of the acts of the virtue of religion, whereas the religious worshipper is the finis quo (the beneficiary) of the acts. I argue that this solution, which is based on a single text of Aquinas (ST II-II.81.7c), is insufficient. After examining Aquinas' theory of action (the doctrine of object, end, and circumstances presented in ST I-II.18), I show how the object of a particular human act can be interpreted as the finis operis (the end of the agent's act). Utilizing this principle of the identity between the object and the finis operis, I argue that the finis operis of religion can be summed up as a threefold sequence of ends: the honor, reverence, and glory of God. As a result, the ultimate beneficiary of acts of religious worship is neither God nor the individual worshipper, but rather the totality of the universe, encapsulated by Aquinas in his notion of divine "glory," that is, the extrinsic manifestation of God's intrinsic goodness within the universe. (shrink)

Related to the research of working conditions, the link between organizational factors and health was traditionally analyzed using linear models. However, the literature analysis suggests inconsistencies in linear models predicting workers’ health levels. To clarify this issue, this exploratory research compares the linear and non-linear relationships between job demands-resources, and the psychological and physical symptoms of employees working in the main five service subsectors: commerce, horeca, public administration, education, and healthcare. With a final sample of 4,047 participants, our study data (...) were extracted from the II Andalusian Working Conditions Survey. Following the theoretical framework of JD-R Model and considering the Vitamin Model theoretical approach for non-linear relationships, our results showed that there were significant differences among the five subsectors analyzed regarding the linear and non-linear relationships between job demands-resources and psychological and physical symptoms of employees. Furthermore, task complexity generated non-linear relationships in higher proportion than time pressure and contact with users. Likewise, non-linear relationships found showed a U-shape. Moreover, the findings of non-linear relationships suggested that medium levels of task complexity should not be exceeded to avoid further negative impact on psychological and physical symptoms for service sector employees, preserving their health. Finally, some general practical implications of work environment interventions are suggested. (shrink)

La teología de Ilia Delio se acerca valientemente hasta las últimas fronteras de la ciencia y la tecnología en nuestro mundo del siglo XXI. Estas fronteras incluyen de modo especial a la mecánica cuántica y al cíborg, y muy cerca de ellas también a la inteligencia artificial y al transhumanismo. Ella insiste en la necesidad de superar lo que denomina el complejo helénico, el marco de comprensión de una metafísica y una cosmología pertenecientes a otra época que no pueden ya (...) por más tiempo servir a la transmisión de la fe. Delio se define a sí misma como una cristiana cíborg y trabaja en una teología nueva para un tiempo nuevo, aunque algunas de sus conclusiones puedan ser rechazadas, su impulso es importante para desarrollar una teología que realmente sea significativa en nuestro mundo. (shrink)

The question addressed here is how Aristotle can characterize the ‘unmoved mover’ that is the ‘first ousia’ and first principle of his metaphysics not only as being alive, but as a model for the best kind of human life. The first step towards understanding this characterization is the distinction between ‘motion’ and ‘activity’ that Aristotle develops in 6th chapter of Metaphysics. Only on the basis of this distinction can we understand how the unmoved mover can be active without being in (...) motion. The second is the argument in De Anima that the soul as principle of life is not any kind of motion, being unmoved even by itself. The soul indeed ‘moves’ in the sense of causing motion, but while remaining itself unmoved. On this basis we see that the meaning of ‘life’ in us is not fundamentally different from its meaning in the divine, and that therefore we can indeed find in the ultimate object of metaphysics a model for how we ourselves are to live. (shrink)

My purpose in this article is to propose an explicitly naturalized account of the experience of present nowness on the basis of two complementary sources: phenomenological analysis and cognitive neuroscience. What I mean by naturalization, and the role cognitive neuroscience plays will become clear as the paper unfolds, but the main intention is to use the consciousness of present time as a study case for the phenomenological framework presented by Depraz in this Special Issue.

Worldwide, vulnerable neighbourhoods of large cities are often the scene of collective violent conflicts linked with migration and ethnic minorities’ struggles for social justice. However, urban conflicts of this kind have not taken place in Spanish cities with high immigration rates, even though the country has been deeply affected by two recent socioeconomic crises (2009 and 2020). This article reports findings of a study aimed at understanding what lies behind this apparent social peace. The research methodology was based on an (...) analysis of secondary socio-economic and socio-relational data from the Spanish Institute of Statistics and from key national surveys and reports. Results confirmed that immigrant population living in the country are strongly segregated in the lower strata of the labour and socioeconomic structure and have been disproportionately affected by the crises. However, research findings also pointed to the existence of strong closed support networks where social capital has been effective at palliating members’ disadvantage and unrest. Drawing on the Theory of Rupture Frames, we argue that this is a fragile and unsustainable social peace, rooted in social injustice, and anticipate that unless actively prevented, uncontrolled conflict will eventually emerge in main cities’ neighbourhoods in Spain. (shrink)